Purdy missed the 49ers' Week 12 contest versus the Green Bay Packers last Sunday with a right shoulder injury—a game San Francisco lost 38–10. The 25-year-old was limited in practice this week on Wednesday and Thursday, and was a full participant on Friday. He's officially listed as questionable for Sunday.

On Saturday night, ESPN's Adam Schefter reported that San Francisco 49ers quarterback Brock Purdy, officially listed as questionable, is expected to start Sunday night against the Buffalo Bills.

QB Brock Purdy injured his shoulder in Week 11 against the Seattle Seahawks and wound up missing the team’s blowout Week 12 loss to the Green Bay Packers.